Blar i forfatter "van der Vlag, Johan"

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    • IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene 

      Thiyagarajan, Dhivya; Pedersen, Hege Lynum; Seredkina, Natalya; Horvei, Kjersti Daae; Arranz, Lorena; Sonneveld, Ramon; Nijenhuis, Tom; van der Vlag, Johan; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-06)
      Recently we described that endonuclease inactive DNase I translocated into the nucleus in response to increased endogenous IL-1β expression. Here, we demonstrate impact and function of translocated DNase I in tubular cells. Effect of cytokines on expression level and nuclear localisation of DNase I and corresponding levels of Fas receptor (FasR) and IL-1β were determined by confocal microscopy, qPCR ...

    • Lupus Nephritis: Enigmas, Conflicting Models and an Emerging Concept 

      Seredkina, Natalya; van der Vlag, Johan; Berden, Jo; Mortensen, Elin Synnøve; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Autoantibodies to components of chromatin, which include double-stranded DNA (dsDNA), histones and nucleosomes, are central in the pathogenesis of lupus nephritis. How anti-chromatin autoantibodies exert their nephritogenic activity, however, is controversial. One model assumes that autoantibodies initiate inflammation when they cross-react with intrinsic glomerular structures such as components ...